We are here to enhance your science and ideally become an integral part of it.
Macromolecular crystallography is a very powerful methodology for obtaining high-resolution structural information on biological molecules. However, depending on the project it may take months or even years to complete.
Chances of success increase significantly once TCSB experts participate in the science behind the project and intellectual exchange between the collaborating scientists flows effectively. This is the recommended mechanism especially for the novice structural biologists with no formal training in protein crystallography. In this case, a TCSB scientist may supervise the structural aspects of the project and co-mentor students/postdocs on sample purification, crystallization, structure determination, analysis as well as publication. This mechanism allows PI’s to recruit students/postdocs with or without structural background since adequate structural mentoring and crystallographic resources is ensured at the TCSB.
Experienced users with formal crystallographic training may use the facility independently as long as they conform to TCSB guidelines. In this model, users will be initially instructed for proper working practice with the instruments, after which they may work individually. TCSB staff is there for you to ensure smooth operation of the facility.
Based on the demand and future resources, the TCSB may provide structural expertise as a service. In this mode, for a flat fee that depends on the complexity of the work, TCSB staff will take your pure macromolecule and perform all the necessary experiments to complete the structural aspects of the project.
Users performing experiments at TCSB which were essential for results described in publications (Articles, Posters or Oral Presentations) should acknowledge the facility and give proper credit to its staff members when applicable.
An example: “Crystallization and X-ray analysis were performed at the Technion Center for Structural Biology (TCSB) of the Lorry I. Lokey Center for Life Sciences and Engineering, and the Russell Berrie Nanotechnology Institute.”